Endocrine Abstracts

RationaleLiver cirrhosis frequently leads to changes in body composition consisting of a loss of lean mass, increased body water and variable alterations of fat mass. Changes in body composition may occur after liver transplantation (LT). Our aim was to study the changes that occur in body composition after LT (in the postoperative period after LT as well as 1 month later). Methods: A body composition study was carried out using th...

Introduction: Pheochromocytomas(PCC) and paragangliomas(PGGLs) are rare neuroendocrine tumors. Management is very complex, this is why physicians involved in the management of these patients need to take into account not only clinical aspects but also genetics of these tumors. We present a group of patients diagnosed of metastatic PGG or PCC, their characteristics and long term follow-up.Methods and design: Descriptive and unicentric study that includes ...

Introduction: Intracranial Idiopathic Hypertension (IIH) is a rare complication of testosterone therapy. It is usually benign, but may result and permanent blindness. Its diagnosis is based on a high CSF (> 25 cm H2O) pressure, in the absence of specific causes. The androgen receptor is expressed in the human choroid plexus, and may enhance the activity of Na+/K+-ATPase, and therefore CSF secretion.Methods: Review of the patient’s cli...

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...

Pheochromocytomas and paragangliomas (PPGL) are infrequent neuroendocrine neoplasms, which develop metastases or aggressive behaviour in 25 % patients. They can be classified into three clusters according to their molecular features; nevertheless, these differences may not stratify patients according to their prognosis. The dysregulation of the splicing process has emerged as a novel feature shared by most cancers, which is associated with an aggressive phenotype in several tu...

Introduction: We have recently reported that the use of cyproterone acetate (CPA) is associated with a highly significant increase of the risk of hypertension development after 5 years (adjusted hazard ratio 0.227, P< 0.001) in young transgender women. Due to the risks associated with the prolonged use of CPA (including the development of meningioma), the EMA presently recommends avoiding the use of doses > 10 mg CPA daily if possible. In fact, acceptable effi...

Introduction: Syndrome of Inappropriate Antidiuretic (SIAD) is the most frequent cause of hyponatremia in parenteral nutrition (PN) patients. Moreover, SIAD may be caused by multiple etiologies (drugs; pulmonary, neurological or abdominal disorders; malignant disease; idiopathic…). Our objective was to evaluate the main etiologies of SIAD in patients receiving PN.Methods: Prospective, non-interventional, multicenter study in 19 Spanish hospitals. F...

Objective: To evaluate the degree of compliance of the glycemic objectives in non-critic-hospitalized patient and determinate the factors associated to the lack of compliance of the aforesaid objectives.Material and method: Retrospective observational study in hospitalized patients during 2014. Adult patient age 18 or older, who had at least two points of care de glucose measurements (capillary blood glucose) during their hospitalization, were included. ...

Objective: To determine the hypoglycaemia prevalence in an old-patient hospitalized and to stablish the factors associated with its appearance and to study the association between the hypoglycaemia with the stay in hospital and the mortality during the hospitalization.Material and method: A retrospective study in which all patients, older than 65 years old that were hospitalized during 2014 and at least two glycemic control have been realised, were inclu...

Introduction: Dumping syndromes are common after bariatric surgery and can present diagnostic and therapeutic challenges in pregnancy.Case report: A 23-year-old female who underwent a RYGB surgery because of morbid obesity in 2013. She had no medical history of diabetes nor any other comorbidity related to obesity. Two years later, her weight had reduced from 128 to 76 kg and also her body mass index (BMI) from 43.8 to 26 kg/m2. She was treate...